A.致命率B.多臓器不全発生率C.SIRS発生率(メタ解析のやさしい解説は第1章の10ページまたはそのQRコードからご覧ください)Pancreas 2013; 42: 640-646. (CS) 6) Wan B, Fu H, Yin J, et al. Efficacy of rhubarb com-bined with early enteral nutrition for the treatment of severe acute pancreatitis: a randomized controlled trial. Scand J Gastroenterol 2014; 49: 1375-1384. (RCT) 7) Stimac D, Poropat G, Hauser G, et al. Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial. Pancreatology 2016; 16: 523-528. (RCT) 8) Li JY, Yu T, Chen GC, et al. Enteral nutrition within 48 hours of admission improves clinical outcomes of acute pancreatitis by reducing complications: a meta-analy-sis. PLoS One 2013; 8: e64926. (MA) 9) Feng P, He C, Liao G, et al. Early enteral nutrition ver-sus delayed enteral nutrition in acute pancreatitis: A PRISMA-compliant systematic review and meta-anal-ysis. Medicine (Baltimore) 2017; 96: e8648. (SR) 10) Song J, Zhong Y, Lu X, et al. Enteral nutrition pro-vided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis. 5. 栄養療法103 図1 早期EN群(48時間以内)を後期ENないしTPN群と比較したメタ解析のForest plot (急性膵炎診療ガイドライン作成ワーキンググループで行ったメタ解析結果より) 2) Zhang XJ, Xing H, Yin FY, et al. Comparison of the efficacy of early enteral nutrition and total enteral nutrition in elderly patients with severe acute pancre-atitis. J Community Med 2015; 13, 45-46. (RCT) 3) Zhang QQ, Jin ZP, Liu LZ. Treatment of early enteral nutrition and enteral nutrition treatment for severe acute pancreatitis. J Clin Med 2016; 3, 7566-7567. (RCT) 4) Sun JK, Mu XW, Li WQ, et al. Effects of early enteral nutrition on immune function of severe acute pancre-atitis patients. World J Gastroenterol 2013; 19: 917-922. (RCT) 5) Wereszczynska-Siemiatkowska U, Swidnicka-Siergie-jko A, Siemiatkowski A, et al. Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. ■ 引用文献 1) Bakker OJ, van Brunschot S, van Santvoort HC, et al; Dutch Pancreatitis Study Group. Early versus on-de-mand nasoenteric tube feeding in acute pancreatitis. N Engl J Med 2014; 371: 1983–1993. (RCT)
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