45015T

12/19

1） Kramer IR, Pindborg JJ, et al. The World Health Organization histological typing of odontogenic tumours. In-troducing the second edition. Eur J Cancer B Oral Oncol. 1993 ; 29B : 169-71. 2） Broders AC. Squamous-cell epithelioma of the lip : study of five hundred and thirty-seven cases. JAMA. 1920 ; 74 : 656-64. 3） Jakobsson PA, Eneroth CM, et al. Histologic classification and grading of malignancy in carcinoma of the lar-ynx. Acta Radiol Ther Phys Biol. 1973 ; 12 : 1-8. 4） Willén R, Nathanson A, et al. Squamous cell carcinoma of the gingiva. Histological classification and grading of malignancy. Acta Otolaryngol. 1975 ; 79 : 146-54. 5） Anneroth G, Hansen LS. A methodologic study of histologic classification and grading of malignancy in oral squamous cell carcinoma. Scand J Dent Res. 1984 ; 92 : 448-68. 6） Yamamoto E, Kohama G, et al. Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity. Cancer. 1983 ; 51 : 2175-80. 7） Yamamoto E, Miyakawa A, et al. Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg. 1984 ; 6 : 938-47. 8） 日本口腔腫瘍学会編．口腔癌取扱い規約第2版．金原出版，東京，2019. 9） Barnes L, Eveson JW, et al. World Health Organization Classification of Tumours, Pathology & Genetics, Head and Neck Tumours, IARC Press, London, p164-79, 2005. 10） Brandwein-Gensler M, Teixeira MS, et al. Oral squamous cell carcinoma : histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005 ; 29 : 167-78. 11） Amin MB, Edge S, et al. AJCC Cancer Staging Manual, 8th ed. Springer, Switzerland, p3-94, 2017. 2018年改訂 : https://cancerstaging.org/references-tools/deskreferences/pages/8eupdates.aspx評価は困難であり，主に手術検体での評価方法である。T1，T2の初期浸潤癌でも，特にDOIが4mm以上の場合，WPOI-5は局所再発や疾患特異的生存率の有意な予測因子とされている11）。しかし，予後を決定する因子は複雑であり，さらなる検討が必要である。参考文献 　　113